# Paola A. Marignani Source: https://hello.cv/paolamarignani ## Links - linkedin | https://www.linkedin.com/in/drpaolamarignani/ - twitter | https://x.com/pmarignani - twitter | https://x.com/CDNWomenSTEM ## Work ### PI | Dalhousie University ## Education ### Dalhousie University | Micro Credential Indigenous Teaching and Learning ### Massachusetts Institute of Technology | Artificial Intelligence in Health Care ### McMaster University | PhD ## Publications ### The Tumor Suppressor Kinase LKB1: Metabolic Nexus Frontiers in Cell and Developmental Biology journal-article ### Single-Cell RNA Sequencing Analysis Using Fluidigm C1 Platform for Characterization of Heterogeneous Transcriptomes. Methods in molecular biology (Clifton, N.J.) journal-article ### Single-cell RNA sequencing for the identification of early-stage lung cancer biomarkers from circulating blood npj Genomic Medicine journal-article ### Targeting mTOR and Glycolysis in HER2-Positive Breast Cancer Cancers journal-article ### Targeting mTOR and Glycolysis in HER2-Positive Breast Cancer Cancers journal-article ### Targeting mTOR and Glycolysis in HER2-Positive Breast Cancer Cancers journal-article ### Profiling non-small cell lung cancer reveals that PD-L1 is associated with wild type EGFR and vascular invasion, and immunohistochemistry quantification of PD-L1 correlates weakly with RT-qPCR PLOS ONE journal-article ### S100A10 Has a Critical Regulatory Function in Mammary Tumor Growth and Metastasis: Insights Using MMTV-PyMT Oncomice and Clinical Patient Sample Analysis Cancers journal-article ### S100A10 Has a Critical Regulatory Function in Mammary Tumor Growth and Metastasis: Insights Using MMTV-PyMT Oncomice and Clinical Patient Sample Analysis Cancers journal-article ### Molecular profiling of non-small cell lung cancer PLoS ONE journal-article ### Prolactin-inducible EDD E3 ubiquitin ligase promotes TORC1 signalling, anti-apoptotic protein expression, and drug resistance in breast cancer cells. American journal of cancer research journal-article ### MA24.11 Loss of Tumour Suppressors is Adequate and Sufficient to Drive Lung Cancer in CRISPR/Cas9 Mice Journal of Thoracic Oncology journal-article ### Ranitidine inhibition of breast tumor growth is B cell dependent and associated with an enhanced antitumor antibody response Frontiers in Immunology journal-article ### Regulation of cell surface protease receptor S100A10 by retinoic acid therapy in acute promyelocytic leukemia (APL)☆ Cell Death and Disease journal-article ### Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3 Oncogene journal-article ### Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice OncoImmunology journal-article ### Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: The challenge ahead Carcinogenesis journal-article ### Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression Carcinogenesis journal-article ### Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss Oncotarget journal-article ### Correction: Loss of lkb1 expression reduces the latency of ErbB2-mediated mammary gland tumorigenesis, promoting changes in metabolic pathways (PLoS ONE) PLoS ONE journal-article ### Loss of lkb1 Expression Reduces the Latency of ErbB2-Mediated Mammary Gland Tumorigenesis, Promoting Changes in Metabolic Pathways PLoS ONE journal-article ### Omega-3 polyunsaturated fatty acid promotes the inhibition of glycolytic enzymes and mTOR signaling by regulating the tumor suppressor LKB1 Cancer Biology and Therapy journal-article ### LKB1 catalytic activity contributes to estrogen receptor α signaling Molecular Biology of the Cell journal-article ### Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells Cancer Biology and Therapy journal-article ### Collagen phagocytosis is regulated by the guanine nucleotide exchange factor Vav2 American Journal of Physiology - Cell Physiology journal-article ### LKB1 catalytically deficient mutants enhance cyclin D1 expression Cancer Research journal-article ### Novel splice isoforms of STRADα differentially affect LKB1 activity, complex assembly and subcellular localization Cancer Biology and Therapy journal-article ### LKB1, the multitasking tumour suppressor kinase Journal of Clinical Pathology journal-article ### Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B Molecular and Cellular Biology journal-article ### LKB1 Associates with Brg1 and Is Necessary for Brg1-induced Growth Arrest Journal of Biological Chemistry journal-article ### Target gene therapy for α-fetoprotein-producing hepatocellular carcinoma by E1B55k-attenuated adenovirus Biochemical and Biophysical Research Communications journal-article ### Vav2 is required for cell spreading Journal of Cell Biology journal-article ### TAZ: a novel transcriptional co‐activator regulated by interactions with 14‐3‐3 and PDZ domain proteins The EMBO Journal journal-article ### TAZ: A novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins EMBO Journal journal-article ### Association of protein kinase Cμ with type II phosphatidylinositol 4- kinase and type I phosphatidylinositol-4-phosphate 5-kinase Journal of Biological Chemistry journal-article ### Diradylglycerol formation is altered by n-3 highly unsaturated fatty acids, with differences between Eicosapentaenoic (EPA) and Docosahexaenoic (DHA) acids Advances in Experimental Medicine and Biology book ### Acyl chain dependence of diacylglycerol activation of protein kinase C activity in vitro Biochemical and Biophysical Research Communications journal-article ### Erratum: Formation of second messenger diradylglycerol in murine peritoneal macrophages is altered after in vivo (n-3)polyunsaturated fatty acid supplementation (Journal of Nutrition (1995) 125 (3030-3040)) Journal of Nutrition journal-article ### Formation of sk-1,2-diradyl glycerol following eicosapentaenoic and docosahexaenoic ethyl ester supplementation w vivo FASEB Journal journal-article ### The formation of diradylglycerol molecular species in murine peritoneal macrophages varies dose-dependently with dietary purified eicosapentaenoic and docosahexaenoic ethyl esters Journal of Nutrition journal-article ### n-3 Polyunsaturated fatty acid-induced changes in the molecular species composition of diradylglycerol in murine peritoneal macrophages remain stable during incubation ex vivo Lipids journal-article ### Formation of second messenger diradylglycerol in murine peritoneal macrophages is altered after in vivo (n-3) polyunsaturated fatty acid supplementation Journal of Nutrition journal-article ## Source Read this profile on Hello.cv: https://hello.cv/paolamarignani Create your free profile at https://hello.cv