Paola A. Marignani

The Tumor Suppressor Kinase LKB1: Metabolic Nexus

Frontiers in Cell and Developmental Biology

Jan 2022

journal-article

Single-Cell RNA Sequencing Analysis Using Fluidigm C1 Platform for Characterization of Heterogeneous Transcriptomes.

Methods in molecular biology (Clifton, N.J.)

Jan 2022

journal-article

Single-cell RNA sequencing for the identification of early-stage lung cancer biomarkers from circulating blood

npj Genomic Medicine

Jan 2021

journal-article

Targeting mTOR and Glycolysis in HER2-Positive Breast Cancer

Cancers

Jan 2021

journal-article

Targeting mTOR and Glycolysis in HER2-Positive Breast Cancer

Cancers

Jan 2021

journal-article

Targeting mTOR and Glycolysis in HER2-Positive Breast Cancer

Cancers

Jan 2021

journal-article

Profiling non-small cell lung cancer reveals that PD-L1 is associated with wild type EGFR and vascular invasion, and immunohistochemistry quantification of PD-L1 correlates weakly with RT-qPCR

PLOS ONE

Jan 2021

journal-article

S100A10 Has a Critical Regulatory Function in Mammary Tumor Growth and Metastasis: Insights Using MMTV-PyMT Oncomice and Clinical Patient Sample Analysis

Cancers

Jan 2020

journal-article

S100A10 Has a Critical Regulatory Function in Mammary Tumor Growth and Metastasis: Insights Using MMTV-PyMT Oncomice and Clinical Patient Sample Analysis

Cancers

Jan 2020

journal-article

Molecular profiling of non-small cell lung cancer

PLoS ONE

Jan 2020

journal-article

Prolactin-inducible EDD E3 ubiquitin ligase promotes TORC1 signalling, anti-apoptotic protein expression, and drug resistance in breast cancer cells.

American journal of cancer research

Jan 2019

journal-article

MA24.11 Loss of Tumour Suppressors is Adequate and Sufficient to Drive Lung Cancer in CRISPR/Cas9 Mice

Journal of Thoracic Oncology

Jan 2018

journal-article

Ranitidine inhibition of breast tumor growth is B cell dependent and associated with an enhanced antitumor antibody response

Frontiers in Immunology

Jan 2018

journal-article

Regulation of cell surface protease receptor S100A10 by retinoic acid therapy in acute promyelocytic leukemia (APL)^☆

Cell Death and Disease

Jan 2018

journal-article

Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3

Oncogene

Jan 2017

journal-article

Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice

OncoImmunology

Jan 2016

journal-article

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: The challenge ahead

Carcinogenesis

Jan 2015

journal-article

Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

Carcinogenesis

Jan 2015

journal-article

Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss

Oncotarget

Jan 2014

journal-article

Correction: Loss of lkb1 expression reduces the latency of ErbB2-mediated mammary gland tumorigenesis, promoting changes in metabolic pathways (PLoS ONE)

PLoS ONE

Jan 2013

journal-article

Loss of lkb1 Expression Reduces the Latency of ErbB2-Mediated Mammary Gland Tumorigenesis, Promoting Changes in Metabolic Pathways

PLoS ONE

Jan 2013

journal-article

Omega-3 polyunsaturated fatty acid promotes the inhibition of glycolytic enzymes and mTOR signaling by regulating the tumor suppressor LKB1

Cancer Biology and Therapy

Jan 2013

journal-article

LKB1 catalytic activity contributes to estrogen receptor α signaling

Molecular Biology of the Cell

Jan 2009

journal-article

Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells

Cancer Biology and Therapy

Jan 2009

journal-article

Collagen phagocytosis is regulated by the guanine nucleotide exchange factor Vav2

American Journal of Physiology - Cell Physiology

Jan 2008

journal-article

LKB1 catalytically deficient mutants enhance cyclin D1 expression

Cancer Research

Jan 2007

journal-article

Novel splice isoforms of STRADα differentially affect LKB1 activity, complex assembly and subcellular localization

Cancer Biology and Therapy

Jan 2007

journal-article

LKB1, the multitasking tumour suppressor kinase

Journal of Clinical Pathology

Jan 2005

journal-article

Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

Molecular and Cellular Biology

Jan 2002

journal-article

LKB1 Associates with Brg1 and Is Necessary for Brg1-induced Growth Arrest

Journal of Biological Chemistry

Jan 2001

journal-article

Target gene therapy for α-fetoprotein-producing hepatocellular carcinoma by E1B55k-attenuated adenovirus

Biochemical and Biophysical Research Communications

Jan 2001

journal-article

Vav2 is required for cell spreading

Journal of Cell Biology

Jan 2001

journal-article

TAZ: a novel transcriptional co‐activator regulated by interactions with 14‐3‐3 and PDZ domain proteins

The EMBO Journal

Jan 2000

journal-article

TAZ: A novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins

EMBO Journal

Jan 2000

journal-article

Association of protein kinase Cμ with type II phosphatidylinositol 4- kinase and type I phosphatidylinositol-4-phosphate 5-kinase

Journal of Biological Chemistry

Jan 1998

journal-article

Diradylglycerol formation is altered by n-3 highly unsaturated fatty acids, with differences between Eicosapentaenoic (EPA) and Docosahexaenoic (DHA) acids

Advances in Experimental Medicine and Biology

Jan 1997

book

Acyl chain dependence of diacylglycerol activation of protein kinase C activity in vitro

Biochemical and Biophysical Research Communications

Jan 1996

journal-article

Erratum: Formation of second messenger diradylglycerol in murine peritoneal macrophages is altered after in vivo (n-3)polyunsaturated fatty acid supplementation (Journal of Nutrition (1995) 125 (3030-3040))

Journal of Nutrition

Jan 1996

journal-article

Formation of sk-1,2-diradyl glycerol following eicosapentaenoic and docosahexaenoic ethyl ester supplementation w vivo

FASEB Journal

Jan 1996

journal-article

The formation of diradylglycerol molecular species in murine peritoneal macrophages varies dose-dependently with dietary purified eicosapentaenoic and docosahexaenoic ethyl esters

Journal of Nutrition

Jan 1996

journal-article

n-3 Polyunsaturated fatty acid-induced changes in the molecular species composition of diradylglycerol in murine peritoneal macrophages remain stable during incubation ex vivo

Lipids

Jan 1996

journal-article

Formation of second messenger diradylglycerol in murine peritoneal macrophages is altered after in vivo (n-3) polyunsaturated fatty acid supplementation

Journal of Nutrition

Jan 1995

journal-article

Paola A. Marignani

Work

Dalhousie University

Education

Dalhousie University

Massachusetts Institute of Technology

McMaster University

Publications

The Tumor Suppressor Kinase LKB1: Metabolic Nexus

Single-Cell RNA Sequencing Analysis Using Fluidigm C1 Platform for Characterization of Heterogeneous Transcriptomes.

Single-cell RNA sequencing for the identification of early-stage lung cancer biomarkers from circulating blood

Targeting mTOR and Glycolysis in HER2-Positive Breast Cancer

Targeting mTOR and Glycolysis in HER2-Positive Breast Cancer

Targeting mTOR and Glycolysis in HER2-Positive Breast Cancer

Profiling non-small cell lung cancer reveals that PD-L1 is associated with wild type EGFR and vascular invasion, and immunohistochemistry quantification of PD-L1 correlates weakly with RT-qPCR

S100A10 Has a Critical Regulatory Function in Mammary Tumor Growth and Metastasis: Insights Using MMTV-PyMT Oncomice and Clinical Patient Sample Analysis

S100A10 Has a Critical Regulatory Function in Mammary Tumor Growth and Metastasis: Insights Using MMTV-PyMT Oncomice and Clinical Patient Sample Analysis

Molecular profiling of non-small cell lung cancer

Prolactin-inducible EDD E3 ubiquitin ligase promotes TORC1 signalling, anti-apoptotic protein expression, and drug resistance in breast cancer cells.

MA24.11 Loss of Tumour Suppressors is Adequate and Sufficient to Drive Lung Cancer in CRISPR/Cas9 Mice

Ranitidine inhibition of breast tumor growth is B cell dependent and associated with an enhanced antitumor antibody response

Regulation of cell surface protease receptor S100A10 by retinoic acid therapy in acute promyelocytic leukemia (APL)☆

Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3

Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: The challenge ahead

Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss

Correction: Loss of lkb1 expression reduces the latency of ErbB2-mediated mammary gland tumorigenesis, promoting changes in metabolic pathways (PLoS ONE)

Loss of lkb1 Expression Reduces the Latency of ErbB2-Mediated Mammary Gland Tumorigenesis, Promoting Changes in Metabolic Pathways

Omega-3 polyunsaturated fatty acid promotes the inhibition of glycolytic enzymes and mTOR signaling by regulating the tumor suppressor LKB1

LKB1 catalytic activity contributes to estrogen receptor α signaling

Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells

Collagen phagocytosis is regulated by the guanine nucleotide exchange factor Vav2

LKB1 catalytically deficient mutants enhance cyclin D1 expression

Novel splice isoforms of STRADα differentially affect LKB1 activity, complex assembly and subcellular localization

LKB1, the multitasking tumour suppressor kinase

Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

LKB1 Associates with Brg1 and Is Necessary for Brg1-induced Growth Arrest

Target gene therapy for α-fetoprotein-producing hepatocellular carcinoma by E1B55k-attenuated adenovirus

Vav2 is required for cell spreading

TAZ: a novel transcriptional co‐activator regulated by interactions with 14‐3‐3 and PDZ domain proteins

TAZ: A novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins

Association of protein kinase Cμ with type II phosphatidylinositol 4- kinase and type I phosphatidylinositol-4-phosphate 5-kinase

Diradylglycerol formation is altered by n-3 highly unsaturated fatty acids, with differences between Eicosapentaenoic (EPA) and Docosahexaenoic (DHA) acids

Acyl chain dependence of diacylglycerol activation of protein kinase C activity in vitro

Erratum: Formation of second messenger diradylglycerol in murine peritoneal macrophages is altered after in vivo (n-3)polyunsaturated fatty acid supplementation (Journal of Nutrition (1995) 125 (3030-3040))

Formation of sk-1,2-diradyl glycerol following eicosapentaenoic and docosahexaenoic ethyl ester supplementation w vivo

The formation of diradylglycerol molecular species in murine peritoneal macrophages varies dose-dependently with dietary purified eicosapentaenoic and docosahexaenoic ethyl esters

n-3 Polyunsaturated fatty acid-induced changes in the molecular species composition of diradylglycerol in murine peritoneal macrophages remain stable during incubation ex vivo

Formation of second messenger diradylglycerol in murine peritoneal macrophages is altered after in vivo (n-3) polyunsaturated fatty acid supplementation

Regulation of cell surface protease receptor S100A10 by retinoic acid therapy in acute promyelocytic leukemia (APL)^☆